Reference of 54608-52-5,Some common heterocyclic compound, 54608-52-5, name is 2-Hydrazinopyrazine, molecular formula is C4H6N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A sample of 2-hydrazinopyrazine was prepared from 2-chloropyrazine and hydrazineusing a procedure analogous to that described in the literature [P.J. Nelson and K.T. Potts, /. Org. Chem.,27. 3243 (1962)], except that the crude product was extracted into 10% methanol/dichloromethane andfiltered, and the filtrate was concentrated and purified by flash chromatography on silica gel, eluting with100% ethyl acetate followed by 10% methanol in dichloromethane. A mixture of 2-hydrazinopyrazine(820 mg, 7.45 mmol), trifluoroacetic acid (2.55 g, 22.4 mmol), and polyphosphoric acid (10 mL) washeated to 140 C with stirring for 18 h. The solution was added to ice and neutralized by the addition ofammonium hydroxide. The aqueous solution was extracted three times with ethyl acetate, washed withbrine, and dried over anhydrous magnesium sulfate. Concentration followed by flash chromatography(silica gel, 1:1 hexane:ethyl acetate, then 100% ethyl acetate) afforded the title compound as a solid.’H NMR (500 MHz, CDC13): 5 8.17-8.20 (m, 2H), 9.54 (s, 1H); C/MS 189 (M+l).
The synthetic route of 54608-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; WO2006/23750; (2006); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem