Adding a certain compound to certain chemical reactions, such as: 27825-20-3, name is Methyl 3-Hydroxy-2-pyrazinecarboxylate, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27825-20-3, Recommanded Product: Methyl 3-Hydroxy-2-pyrazinecarboxylate
Reference Example 27 0.30 g of methyl 3-hydroxy-2-pyrazinecarboxylate was dissolved in 1.5 ML of dimethyl sulfoxide, and thereafter, 0.70 ML of triethylamine and 0.54 g of L-aspartic acid diethyl ester hydrochloride were successively added thereto, followed by stirring at room temperature for 8 hours.. After chloroform and water were added to the reaction solution, the mixture was adjusted to PH 2 with 2 mol/L hydrochloric acid, and the organic layer was separated.. The obtained organic layer was washed with water and then dried with anhydrous magnesium sulfate, and the solvent was removed under reduced pressure.. Toluene and n-hexane were added to the obtained residue, and the precipitate was collected by filtration, so as to obtain 0.18 g of diethyl (2S)-2-{[(3-hydroxy-2-pyrazinyl)carbonyl]amino} butanedioate.1H-NMR(CDCl3)delta: 1.27(3H,t,J=7.2Hz), 1.30(3H,t,J=7Hz), 2.94(1H,dd,J=4.4,17.2Hz), 3.15(1H,dd,J=4.8,17.2Hz), 4.14-4.23(2H,m), 4.24-4.32(2H,m), 4.99-5.02(1H,m), 8.15(1H,d,J=2.6Hz), 8.40(1H,d,J=1.5Hz), 8.78(1H,d,J=5.9Hz), 12.4(1H,brs)
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Reference:
Patent; TOYAMA CHEMICAL CO., LTD.; EP1417967; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem