Adding a certain compound to certain chemical reactions, such as: 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939412-86-9, SDS of cas: 939412-86-9
At 0C To a solution of (3-chloropyrazin-2-yl) methanamine hydrochloride (compound 102) (2.48 g, 13.8 mmol, 1.0 equiv.) In dichloromethane (80 mL) was added triethylamine (5.58 g, 55.2 mmol , 4.0 equivalents) and ((benzyloxy) carbonyl) -L-proline (compound 103) (3.43 g, 13.8 mmol, 1.0 equiv) Stirred at 0 & lt; 0 & gt; C for 15 minutes, A solution of 2- (7-azobenzotriazole) -N, N, N ‘, N’-tetramethyluronium hexafluorophosphate (HATU, 5.50 g, 14.5 mmol, 1.05 equiv) was added and the reaction was allowed to react at 0 C to room temperature for 5 minutes. The reaction solution was diluted with dichloromethane (200 mL), washed successively with ammonium chloride solution (200 mL x 1), saturated sodium bicarbonate solution (200 mL x 1), saturated brine (200 mL x 1), and the organic phase was washed with anhydrous sulfuric acid The sodium was dried, filtered, the filtrate was dry and the residue was purified by column chromatography (eluent: Dichloromethane: methanol = 80: 1) to give benzyl (S) -2 – (((3-chloropyrazin-2-yl) methyl) carbamoyl) pyrrolidine-1-carboxylate (2.85 g , Yield: 55.1%). Light brown oil;
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Reference:
Patent; Dongguan Zhen Xing Beite Pharmaceutical Co., Ltd.; Cai Xiong; Zhong Xianbin; Ye Chunqiang; He Qijie; Tan Shifeng; Qian Changgeng; (44 pag.)CN106588937; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem