Application of 889447-19-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 889447-19-2, name is 2-Chloro-5H-pyrrolo[2,3-b]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2-chloro-5H-pyrrolo[2,3-b]pyrazine (423 mg, 3.09 mmol) in2-methyltetrahydrofuran (10 mL) was added NIS (787 mg,3.39 mmol), and the reaction mixturewas stirred at rt overnight. Saturated aqueous sodium thiosulfate (50 mL) was added to quenchthe reaction, and the resulting mixture was partitioned. The aqueous layer was extracted withEtOAc (50 mL x 2). The combined organic layers were washed with saturated brine (80 mL),dried over anhydrous Na2S04, filtered, and the filtrate was concentrated in vacuo. The residuewas purified by silica gel chromatograph (PE/EtOAc (v/v) = 2011-4/1) to give the title compoundas a white solid (814 mg, 100 %).MS (ESI,neg.ion) m/z: 262.1 [M-Hr.
The synthetic route of 2-Chloro-5H-pyrrolo[2,3-b]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (303 pag.)WO2018/108125; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem