Reference of 13515-06-5,Some common heterocyclic compound, 13515-06-5, name is 5,6-Dimethylpyrazine-2-carboxylic acid, molecular formula is C7H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5,6-dimethylpyrazine acid (about 0.27 mmol, prepared as Example 2), EDCI (0.35mmol) and DMAP (0.027mmol) were dissolved in dry methylene chloride (20mL), the chlorinated hederagenin(152 mg, 0.27 mmol, prepared as Example 4) was then dissolved in dichloromethane (20 ml). It was dropped into 5,6-dimethylpyrazine acid solution within 20 minutes, and stirred at room temperature for 12 hours. It was then diluted with dichloromethane (20 mL), washed with saturated aqueous NaCl solution, dried over anhydrous sodium sulfate, concentrated and purified by column chromatography to obtain a white powder, H-23. Yield: 36% (afterchromatograph with DCM / MeOH, 1% -2%) as a white powder, m.p .: 123.6 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Dimethylpyrazine-2-carboxylic acid, its application will become more common.
Reference:
Patent; Xinhuo Zhiyao (Beijing) Technology Co., Ltd.; Fang Kang; Guo Wenbo; Wang Penglong; Cheng Gang; (26 pag.)CN110964078; (2020); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem