Application of 6966-01-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
PdCl2(PPh3)2 (756.6 mg, 1.078 mmol) was added to a stirred suspension of methyl 3-amino-6-bromo-pyrazine-2-carboxylate (5 g, 21.55 mmol), 2-(4-isopropylsulfonylphenyl)- 4,4,5,5-tetramethyl-l,3,2-dioxaborolane (8.022 g, 25.86 mmol) and 2M aqueous Na2CO3 (32.32 mL, 64.65 mmol) in 1 ,2-dimethoxyethane (60 mL) and the reaction heated at 90 C for 23 hours. The reaction mixture was cooled to ambient temperature and the resultant precipitate isolated by filtration. The solid residue was suspended in water and acidified with 1M HCl. The mixture was stirred for 20 minutes and the precipitate isolated by filtration and dried in vacuo at 50 C to give the sub-title compound as a green solid (3.04 g, 44% Yield). The filtrate was acidified further and extracted with EtOAc (x 3). The combined organic extracts were dried (MgS04), filtered and concentrated in vacuo to give a further portion of the sub-title product (1.13 g, 16% Yield). The products were combined to give the sub-title compound as green solid (4.17 g, 60% Yield). 1H NMR (400.0 MHz, DMSO) delta 1.18 (d, 6H), 3.45 (q, 1H), 7.72 (s, 2H), 7.92 (d, 2H), 8.35 (d, 2H), 9.01 (s, 1H) and 13.25 (br s, 1H) ppm; (ES+) 322.1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-6-bromopyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARRIER, Jean-Damien; DURRANT, Steven, John; YOUNG, Stephen, Clinton; STORCK, Pierre-Henri; VIRANI, Aniza, Nizarali; REAPER, Philip, Michael; PINDER, Joanne; WO2011/143423; (2011); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem