Related Products of 87486-34-8, A common heterocyclic compound, 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, molecular formula is C5H4Br2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step-(iii): Synthesis of 5-bromo- 1 -methyl-3-((4-(morpholine-4-carbonyl) phenyl) amino) pyrazin-2( 1H)-one:Intermediate-8b (0.5g, 1.87mmol), Intermediate-i (0.5 g, 2.49 mmol) in DMA (5 mL) were heated at 110¡ãC for i6hrs. Then the reaction mixture was poured over crushed ice, theprecipitate was filtered, dried under vacuum to get desired product as a yellow solid (400 mg,57percent); 1H NMR (400 MHz, DMSO-d6) oe 9.6 (s, 1H), 8.01 (d, 2H, J=8.8 Hz), 7.40 – 7.38 (m, 3H),3.6-3.45 (m, 1 1H); MS (ES) m/z 395 (M+1).
The synthetic route of 87486-34-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; BORUAH, Anima; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; WO2014/125410; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem