Electric Literature of 486424-37-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 486424-37-7 as follows.
CDI (2.23 g, 13.8 mmol) was added to a suspension of 3-amino-6-bromopyrazine-2- carboxylic acid (2.00 g, 9.17 mmol) in DMF (20 ml). The reaction was stirred at RT for 16h. The reaction mixture was cooled (0 00) then diluted with water (20 ml). The solid wascollected by filtration then washed with the minimum volume of water and cooled (0 00)MeCN then dried under vacuum to afford the product as a yellow solid (2.23 g, 86%).1H NMR (250 MHz, DMSO-d6) O 8.58- 8.52 (m, 2H), 7.96-7.82 (m, 3H), 7.15- 7.07(m, 1H). LC/MS (System A, MeOH quench): mlz (ESl) = 232 [Methyl ester M(79Br)H], 234 [Methyl ester M(81Br)H]), R = 0.87 mi UV purity = 95%.
According to the analysis of related databases, 486424-37-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ENTERPRISE THERAPEUTICS LIMITED; HAY, Duncan, Alexander; SCHOFIELD, Thomas, Beauregard; WENT, Naomi; MCCARTHY, Clive; (108 pag.)WO2019/77340; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem