Related Products of 6863-74-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6863-74-7, name is 6-Chloropyrazine-2-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 6-chloropyrazine-2-carbonitrile (lg, 7.17 mmol) in dioxane (15 mL) was added 4,4,5,5-tetramethyl-2-vinyl-l,3,2-dioxaborolane (2.21 g, 14.33 mmol), Na2C03 (1.52 g, 14.33 mmol), and Pd(dppf)Cl2 (40 mg, 0.072 mmol) under N2. The resulting mixture was stirred at 100 C overnight. After cooling to RT, the mixture was diluted with EtOAc (30 mL), washed with brine, dried over Na2SC>4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography (9% EtOAc in petroleum ether) to give the title compound as a solid. LRMS m/z (Mu+Eta) 132.1 found, 132.1 required.
The chemical industry reduces the impact on the environment during synthesis 6-Chloropyrazine-2-carbonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; LIVERTON, Nigel; LUO, Yunfu; (85 pag.)WO2016/100156; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem