Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 426829-61-0, name is N-Benzyl-6-chloropyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C11H10ClN3
To a stirred solution of benzimidazole (130mg, 1. LMMOL) in anhydrous DMF (5mL) at 0C under N2 was added sodium hydride (56mg, 60% dispersion in oil, 1. 45MMOL) in portions over 2 min. The mixture was stirred at 0C for 15 min and at RT for 60 min. To this was added a solution of (6-CHLORO-PYRAZIN-2-YL)- (L-BENZYL)-AMINE (220mg) in DMF (5mL) and the resulting mixture was then heated at reflux for 18h. The DMF was removed under reduced pressure and the residue diluted with chloroform. The organic layer was washed with water, dried (Na2SO4) and the solvent removed under reduced pressure to furnish the crude product. Column chromatography using dichloromethane-methanol (20: 1 < 10: 1) as eluant separated the product (100mg). H-N. m. r. (CD3) 8 4.66 (d, 2H, J= 5.7Hz, CH2), 5.56 (m, 1H, NH), 7.29-7. 39 (m, 7H, Ar-H), 7.78-7. 89 (m, 2H, Ar-H), 7.92 (s, 1H, pyraz-H), 8.16 (s, 1H, pyraz-H), 8.48 (s, 1H, benzimid-H2). m/z (ES) 302 (M++H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 426829-61-0.
Reference:
Patent; CYTOPIA PTY LTD; WO2003/99811; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem