Synthetic Route of 13484-56-5,Some common heterocyclic compound, 13484-56-5, name is 3-Chloro-6-methoxypyrazin-2-amine, molecular formula is C5H6ClN3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Sodium hexamethyldisilazane (1M solution in THF; 0.82 ml) was added dropwise to amixture of 3-amino-2-chloro-5-methoxypyrazine (0.075 g), 7-[2-(4-acetylpiperazin-l-yl)ethoxy]-4-chloro-5-tetrahydropyran-4-yloxyquinazoline (0.17 g) and THF (2.4 ml) thathad been cooled to 0C and the mixture was stirred at 0C for 5 minutes and at ambienttemperature for 30 minutes. Glacial acetic acid (0.053 ml) was added and the reaction mixturewas evaporated. The residue was purified by column chromatography on silica usingincreasingly polar mixtures of methylene chloride and a 7M methanolic ammonia solution aseluent. The material so obtained was triturated under diethyl ether. There was thus obtainedthe title compound as a solid (0.136 g); NMR Spectrum: (CDC13) 2.04 (m, 2H), 2.1 (s, 3H),2.24 (m, 2H), 2.59 (m, 4H), 2.9 (m, 2H), 3.7-3.5 (m, 6H), 4.0 (s, 3H), 4.08 (m, 2H), 4.25(m, 2H), 4.78 (m, 1H), 6.61 (s, 1H), 6.89 (s, 1H), 7.81 (s, 1H), 8.66 (s, 1H), 9.99 (s, 1H);Mass Spectrum: M+H1″ 558 and 560.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-6-methoxypyrazin-2-amine, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/108711; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem