Electric Literature of 74290-65-6, These common heterocyclic compound, 74290-65-6, name is 3-Bromo-5-methylpyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3-bromo-5-methylpyrazin-2-amine (1 g, 5.3 mmol) in chloroacetaldehyde (5 mL) was heated to 100 C for 1 h. The reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with water. The organic layer was dried over sodium sulphate, filtered and concentrated to get residue. The residue was purified by flash chromatography using 20% ethyl acetate in hexanes to get pure titled compound (0.6 g, 53%). ?HNMR (300 MHz, DMSO- d6): oe 8.40 (d, J = 0.9 Hz, 1H), 8.02 (d, J = 0.6 Hz, 1H), 7.79 (d, J =0.9 Hz, 1H), 2.37 (s, 3H).
Statistics shows that 3-Bromo-5-methylpyrazin-2-amine is playing an increasingly important role. we look forward to future research findings about 74290-65-6.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; KOTRABASAIAH UJJINAMATADA, Ravi; PANDIT, Chetan; (152 pag.)WO2016/185342; (2016); A1;,
Pyrazine – Wikipedia,
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