Adding a certain compound to certain chemical reactions, such as: 56423-63-3, name is 2-Bromopyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56423-63-3, Recommanded Product: 56423-63-3
Under nitrogen protection conditions,(S) -2- amino-3-phenylpropanoic acid (1.6 g, 9.5 mmol), 2-bromopyrazine (1 g, 6.3 mmol) were added sequentially to 50 mL of dry N, N- dimethylacetamide, Potassium carbonate (1.7 g, 12.6 mmol) and cuprous iodide (0.2 g, 0.9 mmol) were added and the temperature was raised to 90 C with stirring.After 48 hours the TLC test showed the reaction was complete and the reaction was allowed to cool to room temperature. 30 mL of ethyl acetate and 10 mL of water were added and the temperature was lowered to 0 C. The pH was adjusted to 3 with 6 M HCl solution. The organic phase was separated and the aqueous phaseThe organic phase was combined, dried over anhydrous sodium sulfate and filtered after drying. The residue was purified by column chromatography on a rotary evaporator (petroleum ether: ethyl acetate = 1: 1) Product 0.7g, yield 46%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromopyrazine, and friends who are interested can also refer to it.
Reference:
Patent; Fudan University; Shao Liming; Xu Yulong; Chen Yiyi; Li Wei; Xie Qiong; (25 pag.)CN107151254; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem