Synthetic Route of 4744-50-7, A common heterocyclic compound, 4744-50-7, name is 2,3-Pyrazinecarboxylic anhydride, molecular formula is C6H2N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example-1; Preparation of 3-(5-chloropyridin-2-yI)-carbamoylpyrazine-2-carboxylic acid2-Amino-5-chloro pyridine (171.2 g) was suspended in 800 ml toluene and mixture was heated to 48-52 C. Pyrazine-2,3-dicarboxylic acid anhydride (100 g) was added to the suspension at same temperature. The resulting reaction mixture was stirred for 2 hrs at 48-52 C. The reaction slurry was cooled to 20-25 C and stirred for 30 min. The solid was filtered and washed with 100 ml toluene. The filtered solid was added to a mixture of 1000 ml water and 100 ml cone. HCl at 10-15C. The solid was stirred for 60 min at 10-15 C and filtered. The solid was slurred in 400 ml water, filtered and washed with 100 ml water.The solid was dried at 60-70 C to yield 17O g of title compound.
The synthetic route of 4744-50-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MATRIX LABORATORIES LTD; WO2008/126105; (2008); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem