Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4774-14-5, name is 2,6-Dichloropyrazine, A new synthetic method of this compound is introduced below., SDS of cas: 4774-14-5
Aniline (265.7 mg, 2.85 mmol) and 2,6-dichloropyrazine (427.2 mg, 2.87 mmol) were dissolve in n-butanol (2.0 mL), and 4.0 M hydrochloric acid in 1,4-dioxane (2 mL) was added. The mixture was heated to 120 C for 96 h, poured in water (30 mL), extracted with ethyl acetate (30 mL), the organic layer was washed with saturated aqueous sodium bicarbonate solution (30 mL) and brine (25 mL), concentrated and purified by chromatography (30 g silica gel, 0.5-1.0% ethyl acetate-dichloromethane) to afford 6-chloro-N-phenylpyrazin-2-amine (225.9 mg, 38% yield) as a dark yellow semi-solid; 1H NMR (400 MHz, CDCl3): delta 8.10 (s, 1H), 7.97 (s, 1H), 7.40-7.35 (m, 4H), 7.17-7.12 (m, 1H), 6.74 (s, 1H); Calcd mass for C10H8ClN4: 205.04; LRMS (ESI) m/z [M+H]+ = 206.20.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kashyap, Sudhir; Sandler, Joel; Peters, Ulf; Martinez, Eduardo J.; Kapoor, Tarun M.; Bioorganic and Medicinal Chemistry; vol. 22; 7; (2014); p. 2253 – 2260;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem