Reference of 113305-94-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
To a stirred mixture of 5-aminopyrazine-2-carbonitrile (542 mg, 4.5 mmol) in THF (20 mL) was slowly added sodium hydride (240 mg, 6.02 mmol) below 15 C. The resulting mixture was stirred at room temperature for 1 hour and compound 106 (1 .0 g, 3.01 mmol) was added. The reaction mixture was stirred at 60 C for 4 hours, quenched with ice-water and extracted with ethyl acetate. The organic layer was dried over Na2SO4, filtered and concentrated to afford the title compound 107 (1.0 g, crude) as a yellow solid, which was used for the next step without further purification.
The synthetic route of 5-Aminopyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMAENGINE, INC.; CAI, Xiong; QIAN, Changgeng; WANG, Yanong Daniel; (98 pag.)WO2017/132928; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem