Reference of 21279-64-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21279-64-1 as follows.
General procedure: Comp. 1a and 2a were prepared using microwave reactor. Special thick-walled tubes intended for use in microwave reactor were filled with a mixture of corresponding starting comp. 1 or 2 (150 mg, 0.952 mmol), 25% aqueous ammonia (2 mL, in excess) and MeOH (2 mL). Tubes fitted with stirrer and closed with a special cap were inserted into the reactor. Reaction conditions for microwave-assisted synthesis were: output 200 W, temperature 95 C, reaction time 30 min using PowerMAX mode.
According to the analysis of related databases, 21279-64-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Servusova, Barbora; Paterova, Pavla; Mandikova, Jana; Kubicek, Vladimir; Kucera, Radim; Kunes, Jiri; Dolezal, Martin; Zitko, Jan; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 450 – 453;,
Pyrazine – Wikipedia,
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