58139-04-1, name is 2-Iodo-3-methoxypyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-Iodo-3-methoxypyrazine
Step 1: To a stirred mixture of sodium iodide (4.89 g, 32.67 mmol) and 2-iodo-3-methoxypyrazine (2.57 g,10.89 mmol) in acetonitrile (30 mL) at rt was added trimethylsilyl chloride (3.55 g, 32.67 mmol). The mixture was heatedat 70 C for 1.5 h. The mixture was cooled to rt and partitioned between a mixture of DCM, MeOH, and aq 2 M HCl. Theorganic layer was separated and the aqueous layer was extracted with additional DCM/MeOH mixture. The combinedorganic layers were dried over MgSO4, filtered, and concentrated under reduced pressure to afford 3-iodopyrazin-2(1H)-one (1.21 g, 50%) as a brown solid that did not require further purification. 1H NMR (500 MHz, DMSO-d6) delta 12.54(br s, 1H), 7.42 (d, J = 3.7 Hz, 1H), 7.17 (d, J = 3.7 Hz, 1H); LCMS (ESI) m/z 223 (M+H)+.
The synthetic route of 58139-04-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ambit Biosciences Corporation; HADD, Michael J.; HOCKER, Michael D.; HOLLADAY, Mark W.; LIU, Gang; ROWBOTTOM, Martin W.; XU, Shimin; (299 pag.)EP2766359; (2016); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem