Electric Literature of 21948-70-9, These common heterocyclic compound, 21948-70-9, name is 2-Methylthiopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of AgClO4 (137mg, 0.67mmol) in MeCN (1mL), 2-methylthiopyrazine (84mg, 0.67mmol) was added and the mixture was stirred at ambient temperature for 5min. The resulting solution was filtered and Et2O (6mL) was then layered on a filtrate. The mixture was left overnight at 5C. The precipitated X-ray quality crystals were collected and dried in air. Yield: 210mg (95%). FT-IR (KBr, cm-1): 413 (w), 432 (vw), 494 (vw), 625 (s), 696 (vw), 741 (w), 762 (w), 843 (m), 974 (m), 1084 (vs), 1144 (s), 1292 (w), 1393 (w), 1441 (w), 1466 (w), 1508 (w). Anal. Calcd: C10H12Ag2Cl2N4O8S2 (663.76): C, 18.0; H, 1.8; N, 8.4; S, 9.6 Found: C, 18.2; H, 1.9; N, 8.5; S, 9.8.
Statistics shows that 2-Methylthiopyrazine is playing an increasingly important role. we look forward to future research findings about 21948-70-9.
Reference:
Article; Rogovoy, Maxim I.; Berezin, Alexey S.; Kozlova, Yuliya N.; Samsonenko, Denis G.; Artem’ev, Alexander V.; Inorganic Chemistry Communications; vol. 108; (2019);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem