Continuously updated synthesis method about 98-97-5

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 98-97-5.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-97-5, name is Pyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H4N2O2

Concentrated sulfuric acid (1.20 mL) was added slowly with vigorous agitation to a mixture of 2.48 g (20 mmol) of 2-pyrazine carboxylic acid (1) and 32 mL (1 mol) of methanol. The mixture was then reux for 12 h. Excess methanol was removed by evaporation and the residue was washed with water. The organic layer was again treated with water and concentrated sodium bicarbonate solution to an alkaline reaction, and then again with water. The product was dried over anhydrous MgSO4, collected by ltration, and distilled.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 98-97-5.

Reference:
Article; Zhang, Fei; Wen, Qing; Wang, She-Feng; Shahla Karim, Baloch; Yang, Yu-Shun; Liu, Jia-Jia; Zhang, Wei-Ming; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 90 – 95;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem