4774-14-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4774-14-5, name is 2,6-Dichloropyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
To a solution of diisopropylamine (23.5 mL, 167.7 mmol) in THF (400 mL) at -20 C. was added n-butyllithium (1.6 M solution in hexanes, 104 mL, 166 mmol) dropwise and the reaction mixture was stirred at the same temperature for 30 minutes (min). Then the reaction mixture was cooled to -78 C. and a solution of 2,6-dichloropyrazine (10 g, 67 mmol) in THF (400 mL) was added drop wise over a period of 1.5 hr. The reaction mixture was stirred for additional 1 hr. Then the reaction mixture was poured on to dry ice and allowed to warm to room temperature over a period of 16 hr. The reaction mixture was treated with 1.5 N HCl (200 mL) and extracted with EtOAc. The EtOAc layer was extracted with saturated sodium bicarbonate solution; the aqueous layer was acidified with 1.5 N HCl, extracted with EtOAc, washed with brine and concentrated to obtain the product as pale yellow solid. The solid thus obtained was not purified further and used as such for the next step.Yield: 9 g (69.5%).1H NMR (300 MHz, DMSO-d6): 8.9 (s, 1H)
The synthetic route of 4774-14-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sudhakar, Anantha; US2011/105497; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem