56423-63-3, Adding a certain compound to certain chemical reactions, such as: 56423-63-3, name is 2-Bromopyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56423-63-3.
To a solution of Compound 18 (40 mg) in DMF (1.0 ml), NaH (5.2 mg, >55% in minerai oil) was added and after stirring for 30 minutes, 2-bromopyrazine (23.8 mg) was added and the mixture was stirred at room temperature for 0.5 hour. [0220] To the reaction mixture, DMSO (1.0 ml) was added and after filtering off the insoluble matter, the filtrate was purified by reverse-phase preparative HPLC to give the titled compound (6.7 mg, colorless oil.) 1H NMR (600MHz, CHLOROFORM-d) delta 8.34 – 8.29 (m, 1 H), 8.24 – 8.18 (m, 1 H), 8.13 – 8.08 (m, 1 H), 6.28 [6.19] (s, 1 H), 5.60 – 5.36 (m, 3 H), 4.24 – 4.13 (m, 1 H), 3.95 – 3.87 (m, 1 H), 3.82 – 3.69 (m, 1 H), 2.35 – 0.76 (m, 22 H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromopyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; ONO, Naoya; KURODA, Shoichi; SHIRASAKI, Yoshihisa; TAKAYAMA, Tetsuo; SEKIGUCHI, Yoshinori; USHIYAMA, Fumihito; OKA, Yusuke; EP2687524; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem