57948-41-1, A common compound: 57948-41-1, name is 3-Bromoimidazo[1,2-a]pyrazine, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
3-((Trimethylsilyl)ethynyl)imidazofl,2-aJpyrazine: A mixture of 3 -bromoimidazo[ 1,2-alpyrazine (0.15 g, 0,76 mmol; prepared according to J. Bradac, el al. .1 Org. Chem. (1977), 42,4197 -4201), 0.09 g (0.91 mmol) of ethynyltrimethylsilane, 0.044 g (0.038 mmol) of Pd(PPh3)4,0.014 g (0.076 rnmol) of Cul, and 0.26 mL (1.52 mmol) of diisopropylethylamine in 3.8 mL ofDMF was heated at 50C overnight under an atmosphere of N2. Upon cooling to ambienttemperature, the reaction mixture was concentrated and the crude product was purified by silicagel flash chromatography (eluted with 50% EtOAc/hexanes) to provide 0.15 g of product: 216m/z (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromoimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; GOZGIT, Joseph, M.; RIVERA, Victor, M.; SHAKESPEARE, William, C.; ZHU, Xiaotian; DALGARNO, David, C.; WO2013/162727; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem