Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56423-63-3, name is 2-Bromopyrazine, A new synthetic method of this compound is introduced below., 56423-63-3
To a stirred solution of 2-bromopyrazin (500mg, 3. immol) in dioxan (5mL) were added N({ 2- [(3- { [(tert-butyldimethylsilyl)oxy] methyl }pyridin-2-yl) sulfanyl] -3-chloro-5-(4,4,5 ,5 – tetramethyl- 1,3 ,2-dioxaborolan-2-yl)phenyl } methyl)-2-methylpropane-2-sulfinamide (2.3 g, 3.7mmol), Na2CO3 (1.Og ,9.4mmol), water (2mL) and degassed for 10 mm in argon atmosphere. Then to it was added Pd(PPh3)4 (363mg, 0.3 lmmol) and again degassed for 5 mm. The reactionmass was heated to 120C for 16 h. Reaction mixture was then cooled to 25C, filtered through celite pad and washed with EtOAc. The separated organic layer was washed with brine solution, dried over sodium sulfate and concentrated under reduced pressure. The crude thus obtained was purified by normal silica column using 0-10% methanol in DCM to get N-({2-[(3-{[(tert-butyldimethylsilyl)oxy] methyl }pyridin-2-yl) sulfanyl] -3-chloro-5- (pyrazin-2-yl)phenyl I methyl)2-methylpropane-2-sulfinamide (450mg) as off white solid. LC-MS: 577.1 [M+H] +
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALANINE, Alexander; BEIGNET, Julien; BLEICHER, Konrad; FASCHING, Bernhard; HILPERT, Hans; HU, Taishan; MACDONALD, Dwight; JACKSON, Stephen; KOLCZEWSKI, Sabine; KROLL, Carsten; SCHAEUBLIN, Adrian; SHEN, Hong; STOLL, Theodor; THOMAS, Helmut; WAHHAB, Amal; ZAMPALONI, Claudia; (623 pag.)WO2017/72062; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem