19847-12-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19847-12-2 name is Pyrazinecarbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 3 :f4aS RJaS)-7a-f2-fluoro-5-f2-fpyrazin-2-yl)-lH-imidazol-5-vDphenvn-5-methYl- 4a. .7.7a -t etrah ydro-4 H – f tiro Gamma3 ,4-d] f 1.3]thiazin-2-amineStep 1 : 2-(lH midazol-2-yl)py 2,2-Diethoxyethanamine (3 g, 2.25 mmol) was dissolved in dry methanol (20 mL). To this was added sodium methoxide (1.22 g, 22.5 mmol, as a 25% solution in methanol). After stirring for 25 minutes at room temperature,, pyrazine-2-carbonitrile (2.37 g, 22.5 mmol) and acetic acid (1.35 g, 22.5 mmol) were added and the subsequent solution was stirred at 50C for 1 hour. MeOH (40 mL) and 6N HC1 (12 mL) were added and the reaction was stirred at reflux overnight. The reaction mixture was cooled to room temperature and partitioned between 1 : 1 Et20 and water (60 mL) and the layers were separated. The aqueous layer was basified to pH 9/10 and extracted with 10% MeOH in DCM. The combined organic extracts were dried (MgSOa), filtered and concentrated to give the desired compound ( 1.49 g yellow solid). 1 H NMR (400 MHz, eOH-d,) delta ppm: 7.67 (s, 1 H), 7.09 (d, J=1.8 Hz, 1 H), 6.99 (d, J=2.5 Hz, 1 H), 5.72 (s, 2 H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazinecarbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD; DIMOPOULOS, Paschalis; HALL, Adrian; KITA, Yoichi; MADIN, Andrew; SHUKER, Nicola Louise; WO2012/93148; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem