As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 313339-92-3 name is 3,5-Dichloropyrazine-2-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 313339-92-3
3,5-dichloropyrazine-2-carbonitrile (500 mg, 2.9 mmol), tert-butyl (R)-2-methylpiperazine-1-carboxylate (460 mg, 2.3 mmol), and K2CO3 (794 mg, 5.75 mmol) were combined in a 40 mLpressure vial. DMF (28 mL) was added and the reaction mixture was allowed to stir at rtovernight. The reaction mixture was then diluted with 3:1 chloroform/IPA (isopropyl alcohol)and washed with saturated, aqueous NH4Cl. The combined organic layers were washed withbrine, dried over magnesium sulfate (MgSO4), and concentrated in vacuo while loading ontosilica gel. The residue was purified by column chromatography (silica gel, eluting with agradient of 0-50% 3:1 EtOAc/EtOH in hexanes to afford tert-butyl (R)-4-(6-chloro-5-cyanopyrazin-2-yl)-2-methylpiperazine-1-carboxylate (I-1, 1.11 g, 3.29 mmol, 114 % yield), which needed to be dried further on the genevac to afford a pale yellow solid. MS (ESI) Calc?dfor (C15H21ClN5O2) [M+H]+, 338; found, 338.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dichloropyrazine-2-carbonitrile, and friends who are interested can also refer to it.
Reference:
Article; Achab, Abdelghani; Augustin, Martin A.; Bass, Alan; Chen, Dapeng; Christopher, Matthew; Fradera, Xavier; Goldenblatt, Peter; Katz, Jason D.; Lampe, John; Lesburg, Charles A.; Li, Chaomin; Lipford, Kathryn; McGowan, Meredeth A.; Methot, Joey L.; Schroeder, Gottfried; Shaffer, Lynsey; Shah, Sanjiv; Witter, David; Zeng, Haoyu; Zhou, Hua; Bioorganic and medicinal chemistry letters; vol. 30; 1; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem