In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 95-58-9, name is 2-Chloro-3-methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 95-58-9
The mixture of 5 g of 2-chloro-3-methylpyrazine, 7.44 mL of benzophenoneimine, 2 g of tris(dibenzylideneacetone)(chloroform)dipalladium (0), 2.48 g of 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl, 5.25 g of sodium t-butoxide, and 150 mL of toluene, was heated overnight under reflux. The reaction mixture was cooled back to room temperature, then diluted with ethyl acetated, and washed with water and with saturated brine in the subsequent order. The organic layer was dried over anhydrous magnesium sulfate. After the insolubles were filtered and the filtrate was concentrated under reduced pressure, 50 mL of 4N hydrogen chloride-1,4-dioxane solution was added to the residue, and the mixture was allowed to stand still for 1 hour. The solution was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography. After the solvent is distilled off, the residue was dissolved in a small amount of chloroform, and hexane was added thereto. The solid thus produced was taken, and dried under reduced pressure to obtain 2.5 g of 3-methyl-2-pyrazineamine [53-1] as an orange solid.
The synthetic route of 95-58-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1790650; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem