33332-25-1, Adding some certain compound to certain chemical reactions, such as: 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33332-25-1.
. Methyl 5-chloropyrazine-2-carboxylate (2.0 g, 1 eq., 11.6 mmol) was dissolved in MeOH (15 mL) and the solution was cooled to 0C. Sodium borohydride (1.1 g, 2.5 eq., 29 mmol) was slowly added and the reaction mixture was stirred at room temperature for 1 h. The reaction mixture was quenched with a saturated solution of NH4Cl (15 mL) and extracted with DCM (215 mL). The organic extracts were dried over Na2SO4 and concentrated in vacuo to furnish the crude product, which was purified by flash chromatography eluting with cyclohexane/EtOAc (0 to 60%) to give the pure title compound as colourless oil (1.59 g, 95%). 1H NMR (400 MHz, DMSO-d6): delta 8.73 (d, J=1.4 Hz, 1H), 8.54 (d, J=1.3 Hz, 1H), 5.68 (t, J=5.8 Hz, 1H), 4.65 (d, J=5.7 Hz, 2H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 33332-25-1.
Reference:
Patent; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; BERTOZZI, Fabio; BANDIERA, Tiziano; PONTIS, Silvia; REGGIANI, Angelo; GIACOMINA, Francesca; DI FRUSCIA, Paolo; US2019/135778; (2019); A1;,
Pyrazine – Wikipedia,
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