24241-18-7, Adding some certain compound to certain chemical reactions, such as: 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24241-18-7.
The suspension of 18b (2.51 g, 10.0 mmol), NaCN (0.59 g,12.0 mmol), CuI (0.95 g, 5.0 mmol) and Pd(PPh3)4 (0.14 g,0.1 mmol) were stirred in DMF (20 mL) at 120 C for 10 h under nitrogen protection. After cooling to room temperature, 10% aqueous solution of Na2S2O3(10 mL) and water(50 mL) were added. The mixture was extracted with ethyl acetate (50 mL ¡Á 3), washed with water (3 ¡Á 50 mL), dried over anhydrous Na2SO4 and concentrated. The residue was purified by chromatography on silica gel eluting with PE/EA (10:1-2:1) to give an off-white solid (1.1 g, yield 55%). 6-Bromo-3-aminopyrazine-2-carbonitrile (19b)Yield: 55%, off-white solid, M.p.: 180-182 C (Lit.183-184 C, Sato et al. 1990a, b). 1H NMR (400 MHz,DMSO-d6): delta 8.45 (s, 1H), 7.62 (s, 2H). 1H NMR (400 MHz,CDCl3):delta 8.30 (s, 1H), 5.28 (s, 2H). 13C NMR (125 MHz,DMSO-d6): delta 156.70, 150.49, 123.64, 115.45, 110.60. EI-MS m/z: 198 (M+, Br79,100), 200 (M+, Br81,98), 171(M+, Br79,-H, -CN, 17), 173 (M+, Br81,-H, -CN, 17),119(M+, -Br, 32), 92 (M+, -Br, -H, -CN, 46).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24241-18-7.
Reference:
Article; Guo, Qi; Xu, Mingshuo; Guo, Shuang; Zhu, Fuqiang; Xie, Yuanchao; Shen, Jingshan; Chemical Papers; vol. 73; 5; (2019); p. 1043 – 1051;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem