Discovery of (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 767340-03-4, name is (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine, This compound has unique chemical properties. The synthetic route is as follows., 767340-03-4

Ligand Metal precursor percentyieldb percent eec config. 15 3 A [Rh(cod) 2]BF4 77 88 R 4 B [Rh(cod)Cl]2 58 76 R 5 C [Rh(cod)Cl]2 15 78 a: Reaction conditions: in TFE, 5 molpercent metal precursor, 5 molpercent ligand, 90 psig H2, 50 ¡ãC, 18 h; b: Assayed by HPLC; c: Assayed by chiral HPLC using a AS-RH chiral column eluting with 20percent acetonitrile/water as the mobile phase.

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Reference:
Patent; MERCK & CO., INC.; SOLVIAS AG; WO2005/97733; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem