Adding some certain compound to certain chemical reactions, such as: 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 486460-21-3. 486460-21-3
((c/s-1-(3-Chlorophenyl)-4-f3-(trifluoromethyl)-5.6-dihvdrori.2.4ltriazolof4.3-a1pyrazin- 7(8H)-yl1cvclohexyl)methyl)-carbamic acid tert-butyl ester and ((^ra/7s-1-(3-chlorophenyl)-4- f3-(triflupsilonoromethyl)-5.6-dihvdrof1.2.41triazolof4.3-a1pyrazin-7(8H)-vncvclohexyl>methyl)- carbamic acid tert-butyl esterSodium triacetoxyborohydride (316mg, 1.49mmol) was added to a solution of [1-(3- chlorophenyl)-4-oxo-cyclohexylmethyl]-carbamic acid tert-butyl ester (360mg, 1.07mmol) and 3-trifluoromethyl-5,6,7,8-tetrahydro-[1 ,2,4]triazolo[4,3-a]pyrazine (286.4mg, 1.49mmol) in 1 ,2-dichloroethane and the mixture was stirred at room temperature for 24h. The reaction was quenched with water and the product was extracted with ethyl acetate. The organic extracts were washed with brine, dried and concentrated in vacuo to give a yellow oil. The oil
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine.
Reference:
Patent; NOVARTIS AG; WO2008/77597; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem