123-32-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 123-32-0 as follows.
A method for preparing 5-methylpyrazine-2-carboxylic acid by catalytic oxidation, firstly, diatomaceous earth, manganese chloride, sodium tungstate,Cobalt nitrate and distilled water were added to the reactor at the following element mass ratio: diatomaceous earth: Mn:W:Co:H2O=1:0.09:0.08:0.14:50,Magnetically stirring at room temperature to make it dispersed and uniformly adsorbed, and then removing water by evaporation.Adding a liquid silica sol with a total mass of 5% of the solid sample and kneading it into a small granular sample of 1-2 mm.The mixture was placed in a muffle furnace and calcined in an air atmosphere at 600 C for 5 hours to obtain Mn-W-Co/diatomaceous earth-supported catalyst particles.10 g of Mn-W-Co/diatomaceous earth catalyst particles were packed into a fixed bed microreactor reaction tube, and the reactor was heated to 330 C.The reaction raw material 2,5-dimethylpyrazine was introduced into a fixed bed reaction tube by bubbling with high-temperature steam at 10 ml/min.Oxygen is introduced into the reaction tube separately at 20 ml/min to cause catalytic oxidation of 2,5-dimethylpyrazine in the catalytic bed.The 5-methylpyrazine-2-carboxylic acid is produced and taken out of the reaction tube by water vapor, condensed, crystallized, and collected.Analysis of 5-methylpyrazine-2-carboxylic acid by gas chromatographyThe yield was 75.6%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 123-32-0, and friends who are interested can also refer to it.
Reference:
Patent; Lanzhou University; Dong Zhengping; (6 pag.)CN109369544; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem