A common compound: 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 23611-75-8
Step 1 :Preparation of6-(6-chloropyrazin-2-yl)-N2,N?-bis (4,4-dfluorocyclohexyl)-1,3,5-triazine-2,4-diamine. To a mixture of methyl 6-chloropyrazine-2-carboxylate (300mg, 1. 74mmol) and N?,N5-di-(4,4-difluorocyclohexanamine)- biguanide (700 mg, 2.10 mmol)in MeOH (8 mL) was added MeONa (340 mg, 6.28 mmol).The reaction mixture was stirred at r.t. overnight, and then partitioned between EtOAc (30 mL) and 1120(3OmL). The organic layerwas separated, washed with brine (30 mL), dried over anhydrous Na2SO4, and concentrated and purified by standard methods to afford the desired product. ?H NIVIR (400MHz, DMSO-d6) 9.48 – 9.32 (m, 111), 8.93 (d,J811z, 111), 7.92 – 7.59 (m, 211), 4.15 -3.95(m, 211), 2.08 – 1.60(m, 1611).LCMS:m/z 460(M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 23611-75-8, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; KONTEATIS, Zenon D.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; ZAHLER, Robert; CAI, Zhenwei; ZHOU, Ding; WO2015/3640; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem