Some common heterocyclic compound, 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, molecular formula is C6H5Cl2N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1458-18-0
A. 2-Amino-5,6-dichloro-3-(hydroxymethyl)pyrazine To 70 ml of dry tetrahydrofuran there was added 2-amino-5,6-dichloro-3-(methoxycarbonyl)pyrazine (8.8 g; 0.04M), potassium borohydride (2.7 g; 0.05M), and lithium chloride (2.1 g; 0.05M), and the mixture was stirred at room temperature overnight (17 hours). The reaction mixture was then diluted with about 200 ml of water and chilled, after which the product crystallized, was filtered and dried (5.3 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1458-18-0, its application will become more common.
Reference:
Patent; Merck & Co., Inc.; US4507299; (1985); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem