Some common heterocyclic compound, 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, molecular formula is C5H2ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 55557-52-3
(90 g, 645 mmol), CH3COOH (1 L) and Raney Ni (20 g) were added to a 2 Lautoclave successively. A reaction was carried out in the autoclave while the reaction solution was stirred under ahydrogen pressure of 1 MPa for 48 hours at atmospheric temperature. After the reaction was completed, the reactionsolution was filtered through diatomite, and a solution of HCl in MeOH (200mL, 6.0N) was used to wash diatomite The filtrate after being concentrated was poured into toluene and the obtained system was stirred, and was thenconcentrated again. The obtained mixture was stirred in MTBE (methyl tert-butyl ether) and was filtered. The filtercake was stirred in MTBE and MeOH and was then filtered to obtain intermediate 2 (40g, yield: 35%) as a brownsolid. LCMS showed a molecular ion peak (M+1) 144.0.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 55557-52-3, its application will become more common.
Reference:
Patent; Hangzhou Sanyintai Pharmaceutical Technology Co., Ltd.; Yin, Jianming; YIN, Jianming; LV, Yubin; LI, Bangliang; (36 pag.)EP3480199; (2019); A1;,
Pyrazine – Wikipedia,
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