1458-18-0, Name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, 1458-18-0, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
The mixture of methyl 3-amino-5, 6-dichloropyrazine-2-carboxylate (4.4 g, 19.91 nMol) , 2- (4-fluorophenyl) -4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolane (3.07 g, 21.9 nMol) in dioxane (50 mL) and water (5 mL ) was added Na 2CO 3 (4.22 g, 39.82 nMol) and dppfPdCl 2 (2.84 g, 3.98 nMol) . Then the mixture was stirred at 100 for 1 h under N 2 atmosphere. Then the mixture was concentrated and residue was poured to water (100 mL) and then extracted with EA (100 mL x 3) . The organic solution was then concentrated to afford the crude product (5.5 g, 98%yield) as a yellow solid which was used for next step without further purification. MS m/z (ESI) [M+H] + = 282.2.
Statistics shows that Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate is playing an increasingly important role. we look forward to future research findings about 1458-18-0.
Reference:
Patent; DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.; QI, Changhe; TSUI, Honchung; ZENG, Qingbei; YANG, Zhenfan; ZHANG, Xiaolin; (399 pag.)WO2020/35052; (2020); A1;,
Pyrazine – Wikipedia,
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