5900-13-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Synthesis of N-(5 -bromo-3 -methochiypyrazin-2- vDformamide [0207][0208]Acetic anhydride (150 ml) was added dropwise to formic acid (150 ml) under ice- cooling, followed by stirring at the same temperature for 25 minutes. A solution of 5-bromo-3- methoxypyrazin-2-ylamine (CAS No.5900-13-0, 38.7 g) in THF (200 ml) was added dropwise to the reaction mixture over 10 minutes, and then the reaction solution was stirred at room temperature for one hour. Ice water was added to the reaction solution, and the precipitated powder was collected by filtration. The resulting powder was washed with water and then air- dried overnight to obtain 41.2 g of the title compound. The property values of the compound are as follows.1 H-NMR (CDCl3 ) delta (ppm): 4.06 (s, 3H), 7.87 (s, IH), 7.87 (brd, J = 11.0 Hz, IH), 9.37 (d, J =11.0 Hz5 IH).
The synthetic route of 5-Bromo-3-methoxypyrazin-2-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eisai R&;D Management CO., LTD.; HASEGAWA, Daiju; KITAZAWA, Noritaka; WO2010/98495; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem