In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 873-42-7 as follows. 873-42-7
To a stirred solution of 3,5-dichloropyrazin-2-amine X-10a (0.80 g, 4.15 mmol) in MeOH (20 mL) was added NaOMe (0.90 g, 16.6 mmol) at room temperature. The reaction mixture was heated at 70 C for 16h. Progress of reaction was monitored by TLC. After completion, the reaction mixture was concentrated under vacuum. The residue was diluted with H20 (15 mL) and extracted with EtOAc (3 c 25 mL). The organic layer was separated, dried over anhydrous Na2S04 and concentrated under vacuum. The crude obtained was purified by combi flash chromatography (20% EtOAc in hexane) to afford 5- chloro-3-methoxypyrazin-2-amine X-10 (0.53 g) as an off-white solid. (0854) Yield: 69%. (0855) 1H NMR (400 MHz, DMSO-cfe) d 3.89 (s, 3H), 6.52 (brs, 2H), 7.53 (s, 1 H).
According to the analysis of related databases, 873-42-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UCB PHARMA GMBH; PEGURIER, Cecile; PROVINS, Laurent; CARDENAS, Alvaro; LEDECQ, Marie; MUELLER, Christa E.; HOCKEMEYER, Joerg; EL-TAYEB, Ali; BOSHTA, Nader; RASHED, Mahmoud; (165 pag.)WO2019/243303; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem