A common heterocyclic compound, 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 33332-25-1.
A round bottomed flask was charged with methyl2-chloropyrazine-5-carboxylate (Lonza, 4.83 g, 28 mmol), 1 -Boc-2(S)-ethyl- 5(R)-methylpiperazine free base (6.4 g, 28 mmol), cesium carbonate (Aldrich, 14 g, 42 mmol) and 1 ,4 dioxane (100 ml). The resulting suspension was stirred at 100 0C for 2 d and then filtered. The solid was washed with ethyl acetate (3X400 ml). The combined organic solutions were concentrated on a rotary evaporator to remove the solvent. The residue was purified by flash chromatography on silica gel using 1 % methanol (containing 10% ammonium hydroxide) in dichloromethane as an eluent to provide A21 (9.0 g, 90%), as a beige solid
The synthetic route of Methyl 5-chloropyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2006/91428; (2006); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem