55557-52-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55557-52-3 name is 3-Chloropyrazine-2-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(3-hydroxy-cyclobutyl) methyl benzoate (1.48g, 7.18mmol, 1.05eq.) In anhydrous THF (2mL) was added to sodium hydride(60%, 274mg, 6.84mmol, 1eq.) In anhydrous THF (30mL) suspension, and the mixture was stirred for 1h at room temperature, and then added 3-Chloro-pyrazine-2-carbonitrile (909mg, 6.84mmol, 1eq.), The reaction mixture was stirred at room temperature for 15h. The mixture was diluted with 50mL of water was added,Then EtOAc (30mL x 2) and extracted. The organic solution was washed with saturated sodium chloride combined (30mL x 2), dried over anhydrous sodium sulfate,Then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: PE / EtOAc (V / V) = 2.7 / 1) to give the title compound as a white solid (1g, 28%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloropyrazine-2-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; East Sunshine Pharmaceutical Co., Ltd. of Guangdong; Ren, Qingyun; Luo, Huichao; Tang, Changhua; Zhang, Jiancun; Zhang, Yingjun; (30 pag.)CN104447583; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem