24241-18-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, A new synthetic method of this compound is introduced below.
Step 1: Synthesis of 5-Bromo-3-trimethylsilanylethynyl-pyrazm-2-yIamine.[0282] To a solution of 3,5-Dibromo-pyrazin-2-ylamine (3.00 g, 11.86 mmol) in DMF(35 ml) was added triethylamine (16 ml), then tetraldstriphenylphine palladium (0) (685 mg,0.59 mmol) and copper(i) iodide (271 mg, 1.42 mmol) were added sequentially. Finallytrimethylsilylacetylene (2.0 ml, 14.3 mmol) was added dropwise. The reaction mixture wasstirred at 120 C for 30 minutes and then directly adsorbed onto silica gel. Purification byflash chromatography on silica gel with a gradient of ethyl acetate/hexane afforded the titlecompound (2.30g, 71% yield) as yellow oil. MS: m/z 270.0/272.0 [MH+].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SGX PHARMACEUTICALS, INC.; WO2006/15124; (2006); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem