23688-89-3,Some common heterocyclic compound, 23688-89-3, name is 6-Chloropyrazine-2-carboxylic acid, molecular formula is C5H3ClN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 5-Chloropyrazine-2-carboxamide (1). 5.0 g of 5-hydroxypyrazine-2-carboxylic acid (0.036 mol) was suspended in 50 mL of dry toluene and treated with thionyl chloride (3 eq., 7.9 mL, 0.108 mol). DMF (10 drops) was added to the reaction mixture as a catalyst. The reaction mixture was heated to reflux for about 1 h. The excess of thionyl chloride was removed by repeated evaporation with dry toluene in vacuo.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Chloropyrazine-2-carboxylic acid, its application will become more common.
Reference:
Article; Servusova, Barbora; Paterova, Pavla; Mandikova, Jana; Kubicek, Vladimir; Kucera, Radim; Kunes, Jiri; Dolezal, Martin; Zitko, Jan; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 450 – 453;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem