In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13301-04-7 as follows. 13301-04-7
A solution of methyl 3,6-dibromopyrazine-2-carboxylate (500 mg, 1.690 mmol, 1 equiv), (3S,4S)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine dihydrochloride (493.05 mg, 2.028 mmol, 1.2 equiv) and DIEA (1091.88 mg, 8.448 mmol, 5.0 equiv) in DMA (10 mL) was stirred for 2 at 55 C. Di-tert-butyl dicarbonate (552.33 mg, 2.531 mmol, 1.5 equiv) was then added and the resulting mixture was stirred for 2 h at room temperature. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water and brine, dried over anhydrous Na2S04 and concentrated. The residue was purified by silica gel column chromatography, eluted with PE/EtOAc =1 : 1 to afford the title compound (615 mg, 2 steps yield 75%) as yellow oil.
According to the analysis of related databases, 13301-04-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NIKANG THERAPEUTICS, INC.; FU, Jiping; LOU, Yan; HE, Yigang; (0 pag.)WO2020/61101; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem