33332-25-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33332-25-1 as follows.
Methyl 5-[(oxan-4-yl)amino]pyrazine-2-carboxylate Methyl 5-chloro-2-pyrazinecarboxylate (507 mg, 2.94 mmol), Et3N (1.08 mL, 7.64 mmol) and 4-aminotetrahydropyran (395 uL, 3.82 mmol) were dissolved in dioxane (5 mL) and heated in a microwave reactor at 100 C. for 20 min. Water (50 mL) and brine (25 mL) were added and the reaction mixture was extracted into EtOAc (2*100 mL), dried (MgSO4) and concentrated in vacuo to give the title compound (236 mg, 33.9%) as a yellow oil. LCMS (ES+): 238.2 [MH]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 33332-25-1, and friends who are interested can also refer to it.
Reference:
Patent; Proximagen Limited; Espensen, Max; Savory, Edward; US2015/258101; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem