A common compound: 5049-61-6, name is Pyrazin-2-amine, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 5049-61-6
Example 2 Synthesis of 3,5-dibromopyrazine-2-ylamine 11.2 ml of bromine in 38 ml of acetic acid were slowly added at 15 C., while stirring, to a solution of 2-aminopyrazine (9.5 g, 100 mmol) and sodium acetate trihydrate (32.6 g) in 150 ml of acetic acid. The addition required about 1-2 hours and it was carried out in the dark. The reaction mixture was stirred at room temperature overnight. The solution was concentrated in vacuo and the brown viscous residue was poured into ice water (150 ml) under stirring. Aqueous 20% sodium hydroxide was added in order to obtain a pH of 8 and extracted with ethyl acetate (4*75 ml). The combined organics were washed with water (2*50 ml) and brine (1*50 ml), dried and concentrated. The crude product was purified by column chromatography (2:1 hexanes and ethyl acetate) to provide the desired compound. HPLC: 8.7 min (98% pure) MS: MH+=251.8 C4H3Br2N3=250.8 g/mol
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5049-61-6, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Nuss, John M.; Ramurthy, Savithri; US2001/34051; (2001); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem