A common heterocyclic compound, 1458-03-3, name is Methyl 3-amino-6-chloropyrazine-2-carboxylate, molecular formula is C6H6ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1458-03-3.
Into a 500 ml three-necked flask, 100 mL of acetic acid was added, and Compound 2 (20 g, 0.11 mol) was added dropwise to a 100 mL aqueous solution of 40% hydrogen bromide at 0C. The reaction was completed after 30 minutes of dropwise addition. A 50 ml aqueous solution of sodium nitrite (20.7 g, 0.33 mol) was added dropwise at a controlled temperature of 0C. After 30 minutes of reaction, the reaction is complete and it is quenched by the dropwise addition of 30 ml of 10% sodium bisulfite solution. Ethyl acetate extraction (200ml¡Á2), dried over 20g of anhydrous sodium sulfate, The mixture was concentrated by suction filtration to obtain a white solid compound 3 (23.3 g, yield 87%).
The synthetic route of Methyl 3-amino-6-chloropyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shaoyuan Science And Technology (Shanghai) Co., Ltd.; Shanghai Shaoyuan Reagent Co., Ltd.; Wei Yuanbo; Guo Tao; Wu Yong; (8 pag.)CN108101857; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem