These common heterocyclic compound, 27398-39-6, name is 3-Chloropyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 27398-39-6
Intermediate 17 (50 mg, 0.079 mmol) was dissolved in NMP (300 uL) and N-ethyl-N- isopropylpropan-2-amine (41.3 mu, 0.237 mmol) and 3-chloropyrazine-2-carboxylic acid (13.78 mg, 0.087 mmol) were added, followed by HATU (36.1 mg, 0.095 mmol). The reaction was allowed to stand for 10 min and then analysed by LCMS and found to be complete. 2,2,2-Trifluoroacetic acid (151 mu, 1.975 mmol) was added and the mixture heated at 120 ¡ãC for 20 min. The mixture was poured into water and extracted with DCM. The organics were dried, filtered and evaporated to give a gum which was purified by RP HPLC (solvent B – minimum 10percent, intermediate 55percent, maximum 95percent) to give compound 48 as a white solid (10 mg, 24percent).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27398-39-6.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN BRANDT, Sven, Franciscus, Anna; GIJSEN, Henricus, Jacobus, Maria; VOS, Ann, Marleen; OEHLRICH, Daniel; (77 pag.)WO2018/162445; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem