113305-94-5, The chemical industry reduces the impact on the environment during synthesis 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, I believe this compound will play a more active role in future production and life.
To a stirred mixture of 5-aminopyrazine-2-carbonitrile (131 mg, 1.09 mmol) in THF (8 mL) was slowly added sodium hydride (73 mg, 1.82 mmol) below 15 C. The resulting mixture was stirred at room temperature for 1 hour and compound 207 (302 mg, 0.91 mmol) was added. The reaction mixture was then stirred at 60 C for 4 hours, quenched with ice-water, and extracted with ethyl acetate. The organic layer was dried over Na2504 and concentrated to afford the title compound 208 (280 mg, crude) as a yellow solid.
The chemical industry reduces the impact on the environment during synthesis 113305-94-5. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PHARMAENGINE, INC.; CAI, Xiong; QIAN, Changgeng; WANG, Yanong Daniel; (98 pag.)WO2017/132928; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem