875781-43-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 875781-43-4 name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The compound 2-bromo-5H-pyrrolo [2,3-b] pyrazine (3.00 g, 15.0 mmol) was dissolved in 1,4-dioxane(60 mL), sodium hydroxide solution (2.0 M, 15.0 mL) and formaldehyde solution (37%, 11.4 mL) were added successively, and the mixture was stirred at room temperature night. The reaction solution was concentrated to give a brown oil which was adjusted to pH = 7 with HCl (1.0 M), precipitated with a pale yellow solid, filtered, The filtrate was extracted with EtOAc / MeOH (v / v) = 5/1, 20 mL x 2) and the organic phase was concentrated and the cake was combined and evaporated to dryness to give 4.0 g of yellow Color solid, yield: 99.0%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Liu, Bing; Huang, Jiuzhong; Zhang, Yingjun; Xue, Yaping; Xing, Wei; Xu, Juan; Wu, Zuping; Yu, Tianxi; (106 pag.)CN106432246; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem