5900-13-0, The chemical industry reduces the impact on the environment during synthesis 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine, I believe this compound will play a more active role in future production and life.
Toa stirred suspension of sodium hydride (60%, 196 mg, 4.9 mmol) and THF (10 mL)at 0C, under N2, was added 5-bromo-3-methoxypyrazin-2-amine (1.00g, 4.9 mmol) in one portion. This was stirred at 0C for 30 min before theaddition of 3,5-dichlorobenzene-l- sulfonyl chloride (120 mg, 0.49 mmol) in oneportion. The reaction was allowed to warm to room temperature and stirred for 2hrs. The reaction was acidified to pH 2 with 2 M HC1, diluted with water (100mL) and extracted with EtOAc (100 ml x 3). The combined organic extracts werewashed with water (100 ml), brine (100 ml), dried ( a2S04), filtered andconcentrated to give the crude product as a brown oil, which was purified usingsilica chromatography (eluent 12% to 50% EtOAc in heptane) to give the titlecompound as a white solid (866 mg, 39%); m z=411.7, 413.6 (MH)+
The chemical industry reduces the impact on the environment during synthesis 5-Bromo-3-methoxypyrazin-2-amine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ACTIVE BIOTECH AB; FRITZSON, Ingela; LIBERG, David; EAST, Stephen; MACKINNON, Colin; PREVOST, Natacha; WO2014/184234; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem